50 μg
CAC07952
245 EUR
Raised in:
Rabbit
Protein number:
Q9UKW4
Use before:
1 year
Shipping requirements:
Blue ice
French translation:
anticorps
Clonality:
Polyclonal
Verified reactivity:
Human, Mouse, Rat
Estimated production time:
3-7 business days
NCBI number:
Please refer to NCBI
Gene number:
Please refer to GenBank
Purity:
Protein G purified, >95%
Group:
Polyclonals and antibodies
Other name:
Guanine nucleotide exchange factor VAV3,VAV-3,VAV3
Notes:
For research use only. Not for diagnostic procedures.
Storage recommendation:
Aliquot and store at -20°C. Minimize freezing and thawing.
Verified applications:
ELISA,WB,IHC. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200
Immunogen:
Recombinant Human Guanine nucleotide exchange factor VAV3 protein (562-674AA)
Properties:
If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
About:
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
Supplementary information:
Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).