Recombinant Human CD16b / FCGR3B Protein, Biotinylated 100µg

Fusion tag:

NA

AP Mol Mass:

20 kDa

Mol Mass:

20 kDa

Expressed Host:

E. coli

Accession:

O75015-1

Group:

recombinants

Sequence:

Met 18-Gly 193

Source:

Recombinants or rec. proteins

Purity:

＞90 % as determined by SDS-PAGE.

Formulation:

Lyophilized from sterile PBS, pH 7.4

Endotoxin:

Please contact us for more information.

Reconstitution:

Please refer to it for detailed information.

Synonym:

CD16;CD16b;Fc gamma RIIIb;FCG3;FCGR3;FCR-10;FCRIII;FCRIIIb

Activity:

Measured by its ability to bind human IgG1 in a functional ELISA.2. Labeling ratio of biotin to protein: 5.51.

Stability and Storage:

Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping:

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Properties:

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Background:

Low affinity immunoglobulin gamma Fc region receptor III-B, also known as Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of inflammation and their activation. FCGR3B may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.