Phospho-IGF-I Receptor (Thr1163) Antibody

GendID:

3480

Weight:

96kDa

GeneAlias:

IGF1R

Gene:

IGF1R

Swiss-Prot:

P08069

Format:

Liquid

Concentration:

1mg/ml

Shipping:

Ice bag

French translation:

anticorps

Clonality:

Polyclonal

Application:

WB,IHC,ELISA

Fragment:

Fab fragment

Epitope:

Phospho Thr1163

Reactivity:

Human,Mouse,Rat

Type:

primary antibody

Unigene:

Hs.643120;Hs.714012;

Application_advice:

WB 1:500-1:2000, IHC 1:50-1:200

Antigen:

Phospho-IGF-I Receptor (Thr1163)

Immunogen:

A synthesized peptide derived from human IGF-I Receptor around the phosphorylation site of Thr1163.

Specificity:

Phospho-IGF-I Receptor (Thr1163) Antibody detects endogenous levels of IGF-I Receptor only when phosphorylated at Thr1163.

Properties:

If you buy Antibodies supplied by Affinity Biosciences they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Purification:

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Storage_Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Description:

IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.