200µL
AF7709
600 EUR
GendID:
3480
Weight:
96kDa
GeneAlias:
IGF1R
Gene:
IGF1R
Swiss-Prot:
P08069
Format:
Liquid
Concentration:
1mg/ml
Shipping:
Ice bag
Application:
WB,ELISA
French translation:
anticorps
Clonality:
Polyclonal
Fragment:
Fab fragment
Antigen:
IGF-I Receptor
Application_advice:
WB 1:500-1:2000
Reactivity:
Human,Mouse,Rat
Type:
primary antibody
Unigene:
Hs.643120;Hs.714012;
Immunogen:
A synthesized peptide derived from human IGF-I Receptor .
Specificity:
IGF-I Receptor Antibody detects endogenous levels of IGF-I Receptor .
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Properties:
If you buy Antibodies supplied by Affinity Biosciences they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Storage_Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Description:
IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.