TNF Receptor Type II antibody

Raised in:

Rabbit

Area of research:

Cancer

Shipping conditions:

Blue Ice

French translation:

anticorps

Category:

Primary Antibody

Tested for:

ELISA; Inhibition; WB

Specificity:

Human TNF receptor type II

Form & Buffer:

Lyophilized from PBS, pH 7.2.

Antibody Subtype:

Polyclonal Antibodies, Purified

Cross Reactivity:

Should be determined by the end user

Usage Recommendations:

ELISA: 0.5-2 ug/ml, Inhibition: 15-20 ug/ml, WB: 0.1-0.2 ug/ml

Type of Immunogen:

TNF receptor type II antibodies were raised in rabbit using highly pure recombinant human sTNF-receptor II ..

Properties:

If you buy Antibodies supplied by fitzgerald they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Storage:

Store at -20 deg C until reconstitution. Following reconstitution product may be stored at 4 deg C in the short term. For long term storage aliquot and freeze at -20 deg C. Avoid repeated freeze/thaw cycles.

Gene:

Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

Description:

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.