Recombinant Human Fc γ RIIIB/FCGR3B/CD16b Protein(C-Fc-6His) 50µg

Activity:

NA

AP Mol Mass:

70 kDa

Accession:

O75015

Mol Mass:

41.7 kDa

Fusion tag:

C-Fc-6His

Expressed Host:

Human cells

Group:

recombinants

Sequence:

Thr20-Gln208

Source:

Recombinants or rec. proteins

Purity:

＞95% as determined by reducing SDS-PAGE.

Reconstitution:

Please refer to it for detailed information.

Endotoxin:

＜1.0 EU per µg as determined by LAL test.

Formulation:

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Shipping:

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Synonym:

Low affinity immunoglobulin gamma Fc region receptor III-B; Fc-gamma RIII-beta; FcR-10; IgG Fc receptor III-1; FCG3; FCGR3; CD16b and FCGR3B.

Stability and Storage:

Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months

Properties:

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Background:

Low affinity immunoglobulin gamma Fc region receptor III-B, also known as Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of inflammation and their activation. FCGR3B may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.