Recombinant Mouse Fc γ RI/FCGR1A/CD64 Protein(C-6His)

Activity:

NA

Fusion tag:

C-6His

Accession:

P26151

Mol Mass:

31.5 kDa

AP Mol Mass:

40-60 kDa

Expressed Host:

Human Cells

Group:

recombinants

Latin name:

Mus musculus

Sequence:

Glu25-Pro297

Source:

Recombinants or rec. proteins

Purity:

＞95% as determined by reducing SDS-PAGE.

Formulation:

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Synonym:

High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI; CD64

Shipping:

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Stability and Storage:

Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months

Test:

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Background:

CD64, also known as Fc-gamma receptor 1 (FcγRI), is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity. After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation. CD64 is composed of a signal peptide, three extracellular immunoglobulin domains of the C2-type used to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 mediates endocytosis, phagocytosis, antibody-dependent cellular cytotoxicity, cytokine release, and superoxide production. It is normally expressed on the surfaces of monocytes and macrophages.