Rat TNF Affinity Purified Polyclonal[TNF]

Products_gene_name:

[TNF]

Products_type:

Antibody

Latin name:

Rattus norvegicus

Group:

Polyclonals and antibodies

Description:

1 of protein A or G purified by MyBioSource will give more specificity than crude serum.

Test:

A high affinity purification column was use to purify TNF Polyclonal[TNF] by MyBioSource by chromatographic size exclusion.

About:

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.

Gene:

Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.