FceRI, alpha (Fc epsilon RI alpha, FCE1A, FCER1A, High Affinity Immunoglobulin epsilon Receptor Subunit alpha, IgE Receptor) (PE)

Additional isotype:

IgE

Concentration:

N/A

Immunoglobulin isotype:

IgG2b

Clone:

10C204

Category:

Antibodies

Clonality:

Monoclonal

Also known as:

FceRI, alpha

Host organism:

Mouse (Mus musculus)

Subcategory:

Mnoclonal antibodies

Source organism:

Human (Homo sapiens)

Tested applications::

Flow Cytometry (FC/FACS)

Other gene names:

FCER1A; FCER1A; FCE1A; FcERI; FCE1A; FcERI

Gene name synonims:

FCER1A; FCER1A; FCE1A; FcERI; FCE1A; FcERI

Gene name:

FCER1A; FCER1A; FCE1A; FcERI; FCE1A; FcERI

Purification method:

Affinity Purified by Protein G affinity chromatography.

Form/Appearance:

Supplied as a lyophilized powder from PBS, 1% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE). Reconstitute with 1ml sterile ddH2O.

Species reactivity:

Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.

Test:

A high affinity purification column was use to purify FceRI, alpha (Fc epsilon RI alpha, FCE1A, FCER1A, Immunoglobulin epsilon Receptor Subunit alpha, IgE Receptor) (PE) by MBS Monoclonals by chromatographic size exclusion.

Storage and shipping:

May be stored at Store the antibody at +4 degrees Celsius. before opening. DO NOT FREEZE! Stable at Store the antibody at +4 degrees Celsius. as an undiluted liquid. Stable for at least 12 months at Keep the antibody refrigerated at +4 degrees Celsius. Temperature variations in the range between +1C to +7C are tolerable. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.

Specificity and cross-reactivity:

Recognizes human FceRI, alpha. Specifically recognizes the extracellular D1 domain of FceRI, alpha. Primarily expressed on mast cells and basophils but expression has also been reported on monocytes, Langerhans cells and dendritic cells from patients with atopic diseases.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.

Other names:

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; High affinity immunoglobulin epsilon receptor subunit alpha; high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha

Properties:

Immunoglobulin E (IgE) kappa or Fc specific antibody is a kind of antibody (or immunoglobulin (Ig) "isotype") that has only been found in mammals. IgE is synthesized by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4). IgEs play a role in allergy and response to parasite infection. High levels of IgEs caused by parasites can lower the allergic reaction of patients to allergens common present in the human environment. As such the parasite history of an allergic patient needs to be taken in consideration as a positive factor.

Description:

The FceRI, alpha (Fc epsilon RI alpha, FCE1A, FCER1A, Immunoglobulin epsilon Receptor Subunit alpha, IgE Receptor) (PE) is a α- or alpha protein sometimes glycoprotein present in blood.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.