TRIO Antibody

Analyses:

WB

Target antigen:

TRIO

Entrez GeneID:

7204

Gene Name:

TRIO

Reacts with species::

human

Raised in:

rabbit

Uniprot ID:

O75962

French translation:

anticorps

Product form:

freeze-dried

Clonality:

Polyclonal antibody

Clone:

Polyclonal antibody

Type of the antibody:

IgG polyclonal antibody

Purification:

Immunogen affinity purified.

Protein Name:

Triple functional domain protein

Gene Full Name:

trio Rho guanine nucleotide exchange factor

Product configuration:

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Solubilization:

The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml

Properties:

If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Synonyms:

ARHGEF23 antibody|PTPRF-interacting protein antibody|tgat antibody|trio antibody|TRIO_HUMAN antibody|Triple functional domain protein antibody

Immunogen:

A synthetic peptide corresponding to a sequence at the C-terminus of human TRIO (787-830aa QLRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQH), identical to the related mouse and rat sequences.

Tips:

The TRIO Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.

Storage condtions:

Keep the TRIO Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.

Related articles:

1. "Entrez Gene: TRIO triple functional domain (PTPRF interacting)". 2. Debant, A., Serra-Pages, C., Seipel, K., O'Brien, S., Tang, M., Park, S.-H., Streuli, M. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc. Nat. Acad. Sci. 93: 5466-5471, 1996. 3. Taviaux, S., Diriong, S., Bellanger, J.-M., Streuli, M., Debant, A. Assignment of TRIO, the trio gene (PTPRF interacting) to human chromosome bands 5p15.1-p14 by in situ hybridization. Cytogenet. Cell Genet. 76: 107-108, 1997.

Background:

Triple functional domain protein is a protein that in humans is encoded by the TRIO gene. This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Additionally, the TRIO protein contains 3 functional domains: a serine/threonine kinase domain and 2 guanine nucleotide exchange factor (GEF) domains for the family of Rho-like GTPases, specific for Rac1 and RhoA, respectively. These domains suggest that this enzyme may play a key role in several signaling pathways that control cell proliferation.