Mouse anti Sodium Calcium Exchanger 1

Clone:

6H2

Antibody is raised in:

Mouse

Antibody's reacts with:

Rabbit

Storage:

-80ºC

Protein number:

see ncbi

Application:

Western Blot

Latin name:

Mus musculus

Antibody's specificity:

No Data Available

Category:

Primary Antibodies

Antigen-antibody binding interaction:

Mouse anti Sodium Calcium Exchanger 1 Antibody

Antibody's reacts with these species:

This antibody doesn't cross react with other species

Antibody come from:

Full-length recombinant sphingomyelin synthase r fusion protein

Other description:

Provided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography

Antibody's suited for:

Antibody can be used for Western blotting (5-10µg/ml). Optimal concentration should be evaluated by serial dilutions.

Description:

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Relevant references:

1. Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC Identification of a family of animal sphingomyelin synthases. EMBO J. 2004 Jan 14;23(1):33-44. Epub 2003 Dec 18.

Warnings:

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.

Test:

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Long description:

Ca2+ plays a critical role in intracellular signaling and thus regulation of calcium balance is critical for the maintenance of this signaling function. The plasma membrane Na+/Ca2+ (NaCX) exchangers mediate Na+-dependent Ca2+ efflux in a wide variety of cell types. NaCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In mammals, at least 5 distinct genes code for the exchangers: Three NaCX (NaCX-1, NaCX-2, and NaCX-3), and two in the NaCKX family (NaCKX-1 and NaCKX-2). NaCX-1 is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling (Matsuoka et al., 1993). NACX-1 may also be a target for protection of the heart and brain from ischemia and reperfusion injury (Hagihara et al., 2005; Bano et al., 2005; Choi, 2005).