Rabbit anti phospho-Vav1 [pY160]

Antibody come from:

n/a

Antibody's reacts with:

Human

Antibody is raised in:

Rabbit

Storage:

-80ºC

Protein number:

see ncbi

Clone:

Polyclonal

Application:

Western Blot

Antibody's specificity:

No Data Available

Category:

Primary Antibodies

Relevant references:

no information yet

Latin name:

Oryctolagus cuniculus

Antigen-antibody binding interaction:

Rabbit anti phospho-Vav1 [pY160] Antibody

Antibody's reacts with these species:

This antibody doesn't cross react with other species

Antibody's suited for:

For use with Adiponectin Receptor 2 polyclonal antibody (Cat. No. X1699P).

Description:

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Warnings:

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.

About:

Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.

Other description:

Provided as solution in phosphate buffered saline with 0.08% sodium azide. Purified from rabbit serum by sequential epitope-specific chromatography. The antibody has been negatively preadsorbed using a non-phosphopeptide corresponding to the site of phosphorylation to remove antibody that is reactive with non-phosphorylated Vav1. The final product is generated by affinity chromatography using a Vav1-derived peptide that is phosphorylated at tyrosine 160.

Long description:

Vav proteins belong to the guanidine nucleotide exchange factor family of proteins. These proteins couple receptors to Rho-GTPases. To date, three members of the Vav family have been identified in mammalian cells: Vav1, Vav2, and Vav3. Vav1 contains multiple protein binding motifs, indicating a role for Vav1 as an adaptor protein linking cell surface receptors to downstream signaling proteins. Vav1 is exclusively expressed in hematopoietic cells and plays a significant role in lymphocyte development and antigen receptor mediated activation of NFAT and NF B, and in more delayed responses such as the production of cytokines, including IL-2, IL-3, IFN- and TNF- . Vav1 is also reported to activate JNK, p21-activated kinase (PAK) and PLC , implicating its critical role in calcium mobilization, and cytoskeletal rearrangement. Activation of several cell surface receptors including integrins, immune response receptors, or growth factor receptors leads to phosphorylation of Vav1 on tyrosine residues including tyrosine 160.