Sodium/hydrogen exchanger 1 - Blocking Peptide

Antibody's reacts with:

Human

Antibody is raised in:

Rabbit

Storage:

-80ºC

Protein number:

see ncbi

Application:

Western Blot

Clone:

not specified

Properties:

blocking peptide

Antibody's specificity:

No Data Available

Category:

Proteins & Peptides

Antigen-antibody binding interaction:

Sodium/hydrogen exchanger 1 - Blocking Peptide

Antibody come from:

Synthetic peptide derived from human NSMAF protein.

Antibody's reacts with these species:

This antibody doesn't cross react with other species

Other description:

Provided as solution in phosphate buffered saline with 0.08% sodium azide.

Test:

You can block the antibody by the specific target amino acid sequence of peptide.

Antibody's suited for:

Antibody can be used for Western blotting (1-5 µg/ml). Optimal concentration should be evaluated by serial dilutions.

Warnings:

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.

Long description:

NHE-1 is involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. NHE-1 plays an important role in signal transduction. Located in the kidney and intestine.

Description:

Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.

Relevant references:

1. OÕBrien, N.W., et al. 'Factor associated with neutral sphingomyelinase activation and its role in cardiac cell death.' Circ Res. 2003 Apr 4;92(6):589-91._x000B__x000B_2. Segui, B., et al. 'CD40 Signals apoptosis through FAN-regulated activation of the sphinogmyelin-ceramide pathway.' J Biol Chem. 1999; 274: 37251Ð37258_x000B__x000B_3. Adam-Klages, S., et al. 'FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase.' Cell. 1996; 86: 937Ð947._x000B__x000B_4. Segui, B., et al. 'Involvement of FAN in TNF-induced apoptosis.' J Clin Invest. 2001; 108: 143Ð151.