hydrogen exchanger 3 Antibody

Modification(s):

None

French translation:

anticorps

Concentration:

1ug per 1ul

Conjugation:

Unconjugated

Subcellular location:

Extracellular

Cross reactivity:

Human, Mouse, Rat

Category:

Primary Antibodies

Clone number:

Polyclonal antibody

Modification site(s):

Unmodified antibody

Clonality:

Polyclonal antibody

Target Antigen:

hydrogen exchanger 3

Tested Applications:

WB, IHC-P, IF(IHC-P)

Also known as:

hydrogen exchanger 3 PAb

Purification method:

This antibody was purified via Protein A.

Long name:

hydrogen exchanger 3 Primary Polyclonal Antibody

Recommended dilutions:

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Specificity:

This is a highly specific antibody against hydrogen exchanger 3.

Cross reactive species details:

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Source:

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NHE3

Storage conditions:

Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.

Properties:

If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Synonym names:

Na+/H+ exchanger 3; NHE 3; NHE-3; NHE3; SL9A3_HUMAN; SLC9A 3; Sodium; Slc9a3; Sodium/hydrogen exchanger 3; Sodium/hydrogen exchanger, apical epithelial; Solute carrier family 9 sodium/hydrogen exchanger, isoform 3; Solute carrier family 9 sodium/hydrogen exchanger, member 3; Solute carrier family 9 member 3; MGC126718; MGC126720.

Background of the target antigen:

NHE-3 are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+) ions. While NHE-1 is ubiquitously expressed, the NHE isoforms 2-8 have distinct tissue- and cell type-dependent expression and inhibitory characteristics. NHE-3 localizes to the apical membrane of renal proximal tubules where it is responsible for most of the sodium transport and fluid reabsorption. NHE-3 translocates to internal pools where it mediates natriuresis when blood pressure increases abruptly. NHE-3 is also expressed in the stomach and functions to protect the mucosa by secreting protons that diffuse into the mucous cells.